Involving Hypoxia-Inducible Factor 1 Engages an Autocrine Activation Loop Cells via the Thioredoxin System and Lactate Stimulates Vasculogenic Stem
نویسندگان
چکیده
Published Ahead of Print 18 August 2008. 10.1128/MCB.00795-08. 2008, 28(20):6248. DOI: Mol. Cell. Biol. Hauer-Jensen, Omaida C. Velazquez and Stephen R. Thom Sorokina, Jonni S. Moore, Thomas K. Hunt, Martin Tatyana N. Milovanova, Veena M. Bhopale, Elena M. Involving Hypoxia-Inducible Factor 1 Engages an Autocrine Activation Loop Cells via the Thioredoxin System and Lactate Stimulates Vasculogenic Stem
منابع مشابه
CALL FOR PAPERS Regulation and Function of Stem Cells in the Cardiovascular System Stem cell mobilization by hyperbaric oxygen
[PDF] [Full Text] [Abstract] , October 15, 2008; 28 (20): 6248-6261. Mol. Cell. Biol. O. C. Velazquez and S. R. Thom T. N. Milovanova, V. M. Bhopale, E. M. Sorokina, J. S. Moore, T. K. Hunt, M. Hauer-Jensen, Autocrine Activation Loop Involving Hypoxia-Inducible Factor 1 Lactate Stimulates Vasculogenic Stem Cells via the Thioredoxin System and Engages an [PDF] [Full Text] [Abstract] , Februa...
متن کاملHyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo.
We hypothesized that oxidative stress from hyperbaric oxygen (HBO(2), 2.8 ATA for 90 min daily) exerts a trophic effect on vasculogenic stem cells. In a mouse model, circulating stem/progenitor cell (SPC) recruitment and differentiation in subcutaneous Matrigel were stimulated by HBO(2) and by a physiological oxidative stressor, lactate. In combination, HBO(2) and lactate had additive effects. ...
متن کاملAndrogens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells.
PURPOSE Androgen deprivation is implicated in reducing neoangiogenesis in prostate cancer (PCA). Androgens regulate the expression of the vascular endothelial growth factor (VEGF); hypoxia stimulates VEGF expression through the activation of the transcriptional factor, hypoxia-inducible factor 1 (HIF-1). We tested the hypothesis that an effect of androgens on VEGF expression is regulated direct...
متن کاملVasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy.
Diabetic patients undergoing hyperbaric oxygen therapies (HBO(2)T) for refractory lower extremity neuropathic ulcers exhibit more than a twofold elevation (p=0.004) in circulating stem cells after treatments and the post-HBO(2)T CD34(+) cell population contains two- to threefold higher levels of hypoxia inducible factors-1, -2, and -3, as well as thioredoxin-1 (p<0.003), than cells present in b...
متن کاملThioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancer.
Hypoxic induction of gene expression occurs mainly via the hypoxia-inducible factor-1 (HIF-1) transcription factor and is a critical step in tumor growth. Cyclooxygenase-2 (COX-2) is commonly overexpressed in non-small cell lung cancer (NSCLC). In this study, we sought to determine the role of HIF-1 in the induction of COX-2 expression during hypoxia. Through sequence comparison of hypoxia-resp...
متن کامل